However, ENHANCE collaborators reported that Vytorin resulted in growth of plaque. It found that Vytorin, a combination pill containing both Zetia and the statin Zocor (simvastatin), proved better than the statin alone at reducing levels of cholesterol.
#IS SIMVASTATIN AN ANTI STROKE TREATMENT TRIAL#
The trial tested the effects of a new cholesterol-lowering medication called Zetia (which, as opposed to the statins, works by decreasing cholesterol absorption in the intestine) on patients with cardiovascular disease. 8)Ī seminal study called the ENHANCE trial was published in 2008. The 4S research team reported a three times greater risk of coronary death in the HPS trial, even though patients' total cholesterol in the 4S trial was decreased to a much lower extent. Ravnskov compares two separate trials of a single statin, simvastatin: a 2002 trial (nicknamed HPS) 6) and a 1994 study (nicknamed 4S) 7). Lack of dose-response cannot be attributed to the knowledge that the statins have other effects on plaque stabilization, as this would not have masked the effect of cholesterol-lowering, considering the pronounced lowering that was achieved. 3) 4) If high LDL-C were causal, the greatest effect should have been seen in patients with the highest LDL-C, and in patients whose LDL-C was lowered the most, but this is not the case. In addition, statin treatment is effective whether the initial LDL-C is high or low. However, statins are just as effective whether cholesterol is lowered by a small amount (as in the unsuccessful non-statin trials) or by more than 40%. The fact that statin treatment lowers both total and cardiovascular mortality in high-risk individuals is taken as evidence that cholesterol lowering is effective. But, does lowering cholesterol actually benefit patients with coronary artery disease, and more importantly, are the effects of statins on patients with heart disease even related to their ability to lower cholesterol? There’s no question that statins can effectively lower cholesterol. Large numbers of patients at risk for cardiovascular disease or stroke are prescribed statins – drugs that are marketed as improving health by lowering cholesterol. 1) Indeed, there is some evidence this type of intervention does the opposite. The actions of statins on the Nuclear Receptors are therefore competitive with Olmesartan, as they reduce or negate Olmesartan's therapeutic activities.Īs the 2008 ENHANCE trial illustrates, while high cholesterol is correlated with increased incidence of diseases, lowering cholesterol does not appear to improve human health. , as they are a very similar molecule, and compete with Olmesartan for many of Olmesartan's molecular binding sites. Statins interfere with the actions of Olmesartan Medication taken regularly by patients on the Marshall Protocol for its ability to activate the Vitamin D Receptor. Based on the Marshall Pathogenesis., these drugs are contraindicated. Because statins may interfere with the Marshall Protocol A curative medical treatment for chronic inflammatory disease. The statins have a range of documented negative effects, some of which may be immunopathological. One strong possibility is that statins exert their effects via the body's nuclear receptors Intracellular receptor proteins that bind to hydrophobic signal molecules (such as steroid and thyroid hormones) or intracellular metabolites and are thus activated to bind to specific DNA sequences which affect transcription., which are intricately connected to innate immune function.
#IS SIMVASTATIN AN ANTI STROKE TREATMENT FULL#
Statins are prescribed even though their full mechanisms of action remain unclear. Hypolipidemic drugs are prescribed - sometimes aggressively so - to lower cholesterol levels in people with or at risk of cardiovascular disease and certain inflammatory diseases such as sarcoidosis. The statins (or HMG-CoA reductase inhibitors) along with other drugs, such as cholestyramine (Questran), comprise the class of hypolipidemic drugs. Related articles: Tests: cholesterol and triglycerides (lipids), Palliative vs.
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